Curr Biol：集中注意力可有效缓解疼痛感

近日，发表文章在世界性著名华尔街日报Cell的子刊Current Biology上的一篇建议书指出，利用精神状态电磁干扰（好在）的方法可以使得肿胀减低，然而这种肿胀缓解减低的现象并不乏善可陈在背部。这项研究成果发现是基于使用高分辨率的骨髓近来磁共振高分辨率技术（fMRI技术），对人们由于干燥引起的肿胀水平透过研究成果，研究成果阐明，精神状态电磁干扰不太可能可以在本部肿胀处理早期选择性肿胀频率的传入。来自阿姆斯特丹-埃和林多夫大学医学院的研究成果者Christian Sprenger表示，这种现象并比如说是一种精神状态现象，而是一种活跃的神经元选择性，可以减缓从脊髓上升至脑干高级区域的肿胀频率。

这种现象关乎到了不可逆的类生物体，这种生物体激发自脑干，在减低肿胀的过程之前扮演着重要角色。研究成果人员让参加者分别完成一个恰当或者一个较难的记忆性侦查，需要他们看看书信的书写内容，同时给参加者脑袋上施以干燥。透过较难侦查的参加者变得心烦意乱时，他们都会深感较小的肿胀，通过fMRI技术看出出这些参加者的脊髓区域活性变得较为低，fMRI通常是用来测定脑干活性的改变。

Sprenger和他的助手然后重复了测试，这次他们获取参加者一种药剂-钠洛酮（抗休克的理想药剂，可以阻止类药剂的现象）或者一般而言的清水流到，整体而言，相较只流到一般而言清水的参加者，使用类药剂糖皮质激素的参加者由于目光密集，引起的肿胀缓解减缓了40%，因此表明不可逆的扮演着重要作用。

研究成果者的发现阐明了精神状态过程可以深入地改变人们的肿胀经历，并且对于病理也有最重要的意义。研究成果者表示，我们的研究成果发现给肿胀性疾病化疗获取了概念化行为化疗的方法。（生物谷：T.Shen编译）

doi:10.1016/j.cub.2012.04.006PMC:PMID:

Attention Modulates Spinal Cord Responses to Pain

Christian Sprenger1, , , Falk Eippert1, Jürgen Finsterbusch1, Ulrike Bingel1, 2, Michael Rose1, Christian Büchel1

Reduced pain perception while being distracted from pain is an everyday example of how cognitive processes can interfere with pain perception [ [1], [2], [3], [4] and [5]]. Previous neuroimaging studies showed distraction-related modulations of pain-driven activations in various cortical and subcortical brain regions [ [6], [7], [8], [9], [10] and [11]], but the precise neuronal mechanism underlying this phenomenon is unclear. Using high-resolution functional magnetic resonance imaging of the human cervical spinal cord in combination with thermal pain stimulation and a well-established working memory task [12], we demonstrate that this phenomenon relies on an inhibition of incoming pain signals in the spinal cord. Neuronal responses to painful stimulation in the dorsal horn of the corresponding spinal segment were significantly reduced under high working memory load compared to low working memory load. At the individual level, reductions of neuronal responses in the spinal cord predicted behioral pain reductions. In a subsequent behioral experiment, using the opioid antagonist naloxone in a double-blind crossover design with the same paradigm, we demonstrate a substantial contribution of endogenous opioids to this mechanism. Taken together, our results show that the reduced pain experience during mental distraction is related to a spinal process and involves opioid neurotransmission.